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Diabetes

There are several forms of diabetes. The most common are Type I Diabetes and Type II Diabetes.

Diabetes type I is associated with damage to cells that produce insulin, resulting in the lack of insulin - the key, which would open the door to the cells to obtain glucose. In diabetes of the second type, insulin is produced, but the its effect on the cells is damaged. Receptor system is damaged, causing the cells to to starve, without receiving the necessary insulin. Both types of diabetes are diseases with very strong autoimmune component.

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Stem cells dramatically weaken the influence of immune system on cells, thus much less forms of oxygen are produced. Cell damage due to oxidation is very often used by the body as a defense mechanism.

In pancreas there are many progenitor cells, which can produce insulin. All ducts are filled with stem cells, which are multiplying and differentiating to produce insulin afterwards. But in some cases this mechanism breaks down: a viral disease may have transferred protein components, and it is a foreign protein. This is a kind of label, by which the body recognizes these cells as foreign and does not allow them to further multiply. The result is a first type of diabetes: insulin is not produced and, therefore, there are problems with metabolism are damaged vessels. The conclusion is simple: if you remove the blockade of autoimmune system, cells begin to multiply and diabetes can be overcome.

Injection of stem cells allows us to obtain a large number of cells producing insulin, and thus remove the symptoms of diabetes. It is already widely applied in medical practice. Many hospitals and medical centers state that Type II diabetes can be cured by means of cellular therapy.

If the cultivation and use of stem cells acquire industrial scale, the main method of diabetes treatment would not be insulin (although this too will remain), but cell therapy.

With its help, the pancreas will recover the function of its insulin-producing cells, and thereby all the unpleasant symptoms of diabetes will be reduced.

Many aged patients with Ischemic Heart Disease often also have Diabetes Type II. After stem cells transplantation, not only their heart function improved, but also their blood sugar dropped essentially, reaching normal values for the their age.

These findings opened a clinical study on the therapeutic effect of systemic transplantations of autologous MSC in patients with Diabetes Type I and Type II. The data show significant therapeutic effect of stem cell therapy in different types of diabetes. We suggest that the main contribution into the therapeutic effect in this case is brought by the attenuation of the autoimmune reaction towards insulin-producing cells and initiation of regenerative processes in the pancreatic tissues.

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